HOME > 心血管再生・先端医療開発講座 > 業績・活動

業績・活動

（１）原著論文

  1. Aonuma T, Takehara N, Maruyama K, Kabara M, Matsuki M, Yamauchi A, Kawabe J, Hasebe N. Apoptosis-resistant cardiac progenitor cells modified with apurinic/apyrimidinic endonuclease/redox factor 1 gene overexpression regulate cardiac repair after myocardial infarction. Stem cells translational medicine. 2016;5:1067-1078
  2. Ota H, Takehara N, Aonuma T, Kabara M, Matsuki M, Yamauchi A, Takeuchi T, Kawabe J, Hasebe N. Association between microalbuminuria predicting in-stent restenosis after myocardial infarction and cellular senescence of endothelial progenitor cells. PloS one. 2015;10:e0123733
  3. Minami Y, Sasaki T, Bochimoto H, Kawabe J, Endo S, Hira Y, Watanabe T, Okumura S, Hasebe N, Ohsaki Y. Prostaglandin i2 analog suppresses lung metastasis by recruiting pericytes in tumor angiogenesis. International journal of oncology. 2015;46:548-554
  4. Matsuki M, Kabara M, Saito Y, Shimamura K, Minoshima A, Nishimura M, Aonuma T, Takehara N, Hasebe N, Kawabe JI. Ninjurin1 is a novel factor to regulate angiogenesis through the function of pericytes. Circulation journal. 2015; 79:1363-1371
  5. Sakamoto N, Sato N, Goto M, Kobayashi M, Takehara N, Takeuchi T, Talib AK, Sugiyama E, Minoshima A, Tanabe Y, Akasaka K, Kawabe J, Kawamura Y, Doi A, Hasebe N. Three cases of corticosteroid therapy triggering ventricular fibrillation in j-wave syndromes. Heart and vessels. 2014;29:867-872
  6. Noro T, Takehara N, Sumitomo K, Takeuchi T, Ishii Y, Kato J, Kawabe J, Hasebe N. Initial reduction of oxidative stress by angiotensin receptor blocker contributes long term outcomes after percutaneous coronary intervention. American journal of cardiovascular disease. 2014;4:159-167
  7. Kabara M, Kawabe J, Matsuki M, Hira Y, Minoshima A, Shimamura K, Yamauchi A, Aonuma T, Nishimura M, Saito Y, Takehara N, Hasebe N. Immortalized multipotent pericytes derived from the vasa vasorum in the injured vasculature. A cellular tool for studies of vascular remodeling and regeneration. Laboratory investigation. 2014;94:1340-1354
  8. Izawa K, Okada M, Sumitomo K, Nakagawa N, Aizawa Y, Kawabe J, Kikuchi K, Hasebe N. Impaired glutathione redox system paradoxically suppresses angiotensin ii-induced vascular remodeling. PloS one. 2014;9:e108115
  9. Asanome A, Kawabe J, Matsuki M, Kabara M, Hira Y, Bochimoto H, Yamauchi A, Aonuma T, Takehara N, Watanabe T, Hasebe N. Nerve growth factor stimulates regeneration of perivascular nerve, and induces the maturation of microvessels around the injured artery. Biochemical and biophysical research communications. 2014;443:150-155
  10. Yamauchi A, Kawabe J, Kabara M, Matsuki M, Asanome A, Aonuma T, Ohta H, Takehara N, Kitagawa T, Hasebe N. Apurinic/apyrimidinic endonucelase 1 maintains adhesion of endothelial progenitor cells and reduces neointima formation. American journal of physiology. Heart and circulatory physiology. 2013;305:H1158-1167
  11. Aburakawa Y, Kawabe J, Okada M, Yamauchi A, Asanome A, Kabara M, Matsuki M, Takehara N, Nakagawa N, Okumura S, Minami Y, Mizukami Y, Yuhki K, Ushikubi F, Hasebe N. Prostacyclin stimulated integrin-dependent angiogenic effects of endothelial progenitor cells and mediated potent circulation recovery in ischemic hind limb model. Circulation journal. 2013;77:1053-1062
  12. Nakagawa N, Yuhki K, Kawabe J, Fujino T, Takahata O, Kabara M, Abe K, Kojima F, Kashiwagi H, Hasebe N, Kikuchi K, Sugimoto Y, Narumiya S, Ushikubi F. The intrinsic prostaglandin e2-ep4 system of the renal tubular epithelium limits the development of tubulointerstitial fibrosis in mice. Kidney international. 2012;82:158-171
  13. Nakagawa N, Ota H, Tanabe Y, Kabara M, Matsuki M, Chinda J, Sakamoto N, Fujino T, Takehara N, Takeuchi T, Kawabe J, Sato N, Kawamura Y, Fukuhara T, Ikuta K, Kikuchi K, Hasebe N. A case of idiopathic systemic capillary leak syndrome with high serum levels of g-csf on exacerbation. Internal medicine. 2011;50:597-600
  14. Nakagawa N, Maruyama H, Ishihara T, Seino U, Kawabe J, Takahashi F, Kobayashi M, Yamauchi A, Sasaki Y, Sakamoto N, Ota H, Tanabe Y, Takeuchi T, Takenaka T, Kikuchi K, Hasebe N. Clinical and genetic investigation of a japanese family with cardiac fabry disease. Identification of a novel alpha-galactosidase a missense mutation (g195v). International heart journal. 2011;52:308-311
  15. Kawabe J, Yuhki K, Okada M, Kanno T, Yamauchi A, Tashiro N, Sasaki T, Okumura S, Nakagawa N, Aburakawa Y, Takehara N, Fujino T, Hasebe N, Narumiya S, Ushikubi F. Prostaglandin i2 promotes recruitment of endothelial progenitor cells and limits vascular remodeling. Arteriosclerosis, thrombosis, and vascular biology. 2010;30:464-470
  16. Tashiro N, Sato N, Talib AK, Talib AK, Saito E, Okura M, Yamaki M, Nakagawa N, Sakamoto N, Ota H, Tanabe Y, Takeuchi T, Akasaka K, Kawabe J, Kawamura Y, Hasebe N. Brugada syndrome case: Difficult differentiation between a concealed form and tricyclic antidepressant-induced brugada sign. Internal medicine. 2009;48:1535-1539
  17. Okumura S, Vatner DE, Kurotani R, Bai Y, Gao S, Yuan Z, Iwatsubo K, Ulucan C, Kawabe J, Ghosh K, Vatner SF, Ishikawa Y. Disruption of type 5 adenylyl cyclase enhances desensitization of cyclic adenosine monophosphate signal and increases akt signal with chronic catecholamine stress. Circulation. 2007;116:1776-1783
  18. Kawabe J, Okumura S, Nathanson MA, Hasebe N, Ishikawa Y. Caveolin regulates microtubule polymerization in the vascular smooth muscle cells. Biochemical and biophysical research communications. 2006;342:164-169
  19. Yuhki K, Kawabe J, Ushikubi F. Fat, keeping the heart healthy? Nature medicine. 2005;11:1048-1049
  20. Okada M, Hasebe N, Aizawa Y, Izawa K, Kawabe J, Kikuchi K. Thermal treatment attenuates neointimal thickening with enhanced expression of heat-shock protein 72 and suppression of oxidative stress. Circulation. 2004;109:1763-1768
  21. Kawabe J, Okumura S, Lee MC, Sadoshima J, Ishikawa Y. Translocation of caveolin regulates stretch-induced erk activity in vascular smooth muscle cells. American journal of physiology. Heart and circulatory physiology. 2004;286:H1845-1852
  22. Okumura S, Takagi G, Kawabe J, Yang G, Lee MC, Hong C, Liu J, Vatner DE, Sadoshima J, Vatner SF, Ishikawa Y. Disruption of type 5 adenylyl cyclase gene preserves cardiac function against pressure overload. Proceedings of the National Academy of Sciences of the United States of America. 2003;100:9986-9990
  23. Okumura S, Kawabe J, Yatani A, Takagi G, Lee MC, Hong C, Liu J, Takagi I, Sadoshima J, Vatner DE, Vatner SF, Ishikawa Y. Type 5 adenylyl cyclase disruption alters not only sympathetic but also parasympathetic and calcium-mediated cardiac regulation. Circulation research. 2003;93:364-371
  24. Iwamoto T, Okumura S, Iwatsubo K, Kawabe J, Ohtsu K, Sakai I, Hashimoto Y, Izumitani A, Sango K, Ajiki K, Toya Y, Umemura S, Goshima Y, Arai N, Vatner SF, Ishikawa Y. Motor dysfunction in type 5 adenylyl cyclase-null mice. The Journal of biological chemistry. 2003;278:16936-16940
  25. Fujino T, Hasebe N, Kawabe J, Fujita M, Fukuzawa J, Tobise K, Kikuchi K. Effect of beta-adrenoceptor antagonist and angiotensin-converting enzyme inhibitor on hypertension-associated changes in adenylyl cyclase type v messenger rna expression in spontaneously hypertensive rats. Journal of cardiovascular pharmacology. 2003;41:720-725
  26. Matsusaka T, Hasebe N, Jin YT, Kawabe J, Kikuchi K. Magnesium reduces myocardial infarct size via enhancement of adenosine mechanism in rabbits. Cardiovascular research. 2002;54:568-575
  27. Kawabe JI, Grant BS, Yamamoto M, Schwencke C, Okumura S, Ishikawa Y. Changes in caveolin subtype protein expression in aging rat organs. Molecular and cellular endocrinology. 2001;176:91-95
  28. Aizawa Y, Kawabe J, Hasebe N, Takehara N, Kikuchi K. Pioglitazone enhances cytokine-induced apoptosis in vascular smooth muscle cells and reduces intimal hyperplasia. Circulation. 2001;104:455-460
  29. Takehara N, Kawabe J, Aizawa Y, Hasebe N, Kikuchi K. High glucose attenuates insulin-induced mitogen-activated protein kinase phosphatase-1 (mkp-1) expression in vascular smooth muscle cells. Biochimica et biophysica acta. 2000;1497:244-252
  30. Kawabe J, Aizawa Y, Takehara N, Hasebe N, Kikuchi K. Glucose modifies the cross-talk between insulin and the beta-adrenergic signalling system in vascular smooth muscle cells. Journal of hypertension. 2000;18:1457-1464
  31. Ebina T, Kawabe J, Katada T, Ohno S, Homcy CJ, Ishikawa Y. Conformation-dependent activation of type ii adenylyl cyclase by protein kinase c. Journal of cellular biochemistry. 1997;64:492-498
  32. Iwami G, Kawabe J, Ebina T, Cannon PJ, Homcy CJ, Ishikawa Y. Regulation of adenylyl cyclase by protein kinase a. The Journal of biological chemistry. 1995;270:12481-12484
  33. Iwami G, Akanuma M, Kawabe J, Cannon PJ, Homcy CJ, Ishikawa Y. Multiplicity in type v adenylylcyclase: Type v-a and type v-b. Molecular and cellular endocrinology. 1995;110:43-47
  34. Kawabe J, Iwami G, Ebina T, Ohno S, Katada T, Ueda Y, Homcy CJ, Ishikawa Y. Differential activation of adenylyl cyclase by protein kinase c isoenzymes. The Journal of biological chemistry. 1994;269:16554-16558
  35. Kawabe J, Ebina T, Ismail S, Kitchen DB, Homcy CJ, Ishikawa Y. A novel peptide inhibitor of adenylyl cyclase (ac). A peptide from type v ac directly inhibits ac catalytic activity. The Journal of biological chemistry. 1994;269:24906-24911
  36. Ogawa Y, Kawabe J, Onodera S, Tobise K, Morita K, Harada T, Hirayama T, Takeda A. Role of endothelium in biphasic hypoxic response of the isolated pulmonary artery in the rat. Japanese circulation journal. 1993;57:228-236
  37. Katsushika S, Kawabe J, Homcy CJ, Ishikawa Y. In vivo generation of an adenylylcyclase isoform with a half-molecule motif. The Journal of biological chemistry. 1993;268:2273-2276
  38. Ogawa Y, Kawabe J, Morita K, Harada T, Hirayama T, Takeda A, Tobise K, Onodera S. Role of endothelium in hypoxia-induced contraction of isolated rat pulmonary artery. Japanese journal of pharmacology. 1992;58 Suppl 2:325P
  39. Kawabe J, Ohsaki Y, Onodera S. Down-regulation of protein kinase c potentiates atrial natriuretic peptide-stimulated cgmp accumulation in vascular smooth-muscle cells. Biochimica et biophysica acta. 1992;1175:81-87
  40. Katsushika S, Chen L, Kawabe J, Nilakantan R, Halnon NJ, Homcy CJ, Ishikawa Y. Cloning and characterization of a sixth adenylyl cyclase isoform: Types v and vi constitute a subgroup within the mammalian adenylyl cyclase family. Proceedings of the National Academy of Sciences of the United States of America. 1992;89:8774-8778
  41. Ishikawa Y, Katsushika S, Chen L, Halnon NJ, Kawabe J, Homcy CJ. Isolation and characterization of a novel cardiac adenylylcyclase cdna. The Journal of biological chemistry. 1992;267:13553-13557
  42. Kawabe J, Ohsaki Y, Onodera S, Inoue H, Hirayama T, Akiba Y, Osanai S, Sakai H, Ishida S, Nakano H, et al. [effects of chronic volume loading on atrial natriuretic peptide release in human]. Kokyu to junkan. Respiration & circulation. 1990;38:1121-1125

（２）総説論文

  1. Kawabe J, Hasebe N. Role of the vasa vasorum and vascular resident stem cells in atherosclerosis. BioMed research international. 2014;2014:701571
  2. Yuhki K, Kojima F, Kashiwagi H, Kawabe J, Fujino T, Narumiya S, Ushikubi F. Roles of prostanoids in the pathogenesis of cardiovascular diseases: Novel insights from knockout mouse studies. Pharmacology & therapeutics. 2011;129:195-205
  3. Yuhki K, Kashiwagi H, Kojima F, Kawabe J, Ushikubi F. Roles of prostanoids in the pathogenesis of cardiovascular diseases. International angiology. 2010;29:19-27
  4. Kawabe J, Ushikubi F, Hasebe N. Prostacyclin in vascular diseases. – recent insights and future perspectives. Circulation journal. 2010;74:836-843

（３）産業財産権

  1. 川辺淳一（発明代表者） 特許5880867号　（登録日2-12-2016)
    Ape1遺伝子導入による高機能化幹細胞前駆細胞　特許権者　旭川医科大学　
  2. 川辺淳一（発明代表者）特願2015-151601　
    毛細血管由来幹細胞　その用途及び製造方法　特許権者　旭川医科大学　
  3. 川辺淳一（発明代表者）特願2012-024854　
    末梢組織の毛細血管構成細胞の不死化細胞株　特許権者　旭川医科大学
  4. 川辺淳一（発明代表者）国際特許申請(PCT/JP2011/004508)　
    Ape1遺伝子導入による高機能化幹細胞前駆細胞　特許権者　旭川医科大学

（４）招待講演等

  1. 川辺淳一「Novel adhesion molecule, Ninjurin1 for capillary formation through endothelial-pericyte interaction」
    第93回　日本生理学会大会　シンポジウム　札幌 3月22日2016
  2. 川辺淳一　「Adventitial Angiogenesis and Vascular Remodeling – New role of Capillary Pericytes in Neovessels-」
    第80回　日本循環器学会　学術集会　シンポジウム　仙台 3月20日2016　
  3. 川辺淳一「毛細血管の秘めた能力‐capillary stem cellsによる臓器再生療法－」第63回日本輸血・細胞治療学会総会　シンポジウム　東京 5月29日2015
  4. 川辺淳一「血管再生と血管外膜：微小血管の成熟化と周細胞」
    第47回日本動脈硬化学会総会　シンポジウム　仙台 7月10日2015
  5. 川辺淳一「組織再生における幹細胞様ペリサイトcapillary stem cells (CapSCs)の役割」　シンポジウム主催　第23回日本血管生物医学学会学術集会　神戸 12月12日2015
  6. 川辺淳一「毛細血管幹細胞と組織再生」　
    第26回北海道輸血シンポジウム　招待講演　札幌7月26日2014
  7. 川辺淳一「生命の母なる海　毛細血管のはなし　‐組織再生そしてアンチエージングにむけて－」
    北海道発　再生医療フォーラム（道庁主催）　札幌10月29日2013　
  8. 川辺淳一「毛細血管からみえてくる新しい病態理解　毛細血管幹細胞と組織リモデリング」　クリニカルサイエンス談話会 (北大主催)　札幌3月27日2013

競争的研究資金

公的研究助成

  1. 平成29-31年度　基盤研究（B）新規因子による血管成熟機構の解明と　動脈硬化に対する治療法の開発　　川辺淳一（研究代表者）
  2. 平成28-30年度　Oide CapiSEA 毛細血管幹細胞（CapSC）の再生医療における新規細胞ソースとしての開発　川辺淳一（研究代表者）　官民共同参画（第一三共、三菱UFJキャピタル、（独）中小機構）ファンドによる臨床実用化オープンイノベーションプロジェクト
  3. 平成26-27年度　科学技術振興機構（JST）　研究成果最適展開支援プログラム　北海道臨床開発機構（A-step）、毛細血管幹細胞の治療応用にむけた基礎研究　川辺淳一（研究代表者）
  4. 平成25-27年度　基盤研究（C）再生医療開発にむけた間葉系幹細胞様の毛細血管周細胞の機能解明　　川辺淳一（研究代表者）
  5. 平成23-24年度　科学技術振興機構（JST）　研究成果最適展開支援プログラム　A-step　Ape1遺伝子導入による再生療法に有用な細胞機能改善法の開発　川辺淳一（研究代表者）
  6. 平成22-24年度　基盤研究（C）障害血管リモデリングおよび血管外膜微小血管新生における神経再生因子の役割　　川辺淳一（研究代表者）
  7. 平成22-24年度　基盤研究（C）骨髄由来内皮前駆細胞におけるプロスタノイドの包括的役割解明　研究分担者
  8. 平成21-22年度　科学技術振興機構（JST）シーズ発掘試験　内皮前駆細胞抑制剤drug delivery systemの開発　川辺淳一（研究代表者）
  9. 平成20-22年度　基盤研究（C）骨髄由来血管内皮前駆細胞の制御によるがん治療の検討　研究分担者
  10. 平成18-20年度　基盤研究（C）プロスタノイドの血管病変形成における役割-骨髄細胞分化に及ぼす影響‐川辺淳一（研究代表者）
  11. 平成17-19年度　基盤研究（C） Vascular stiffnessにおよぼすmechanical stressの役割、研究分担者

公的研究助成（若手研究医指導）

  1. 平成29-31年度　若手研究（B）周細胞の多分化能を制御する新規因子の機能解析　研究代表者　鹿原真樹
  2. 平成27-28年度　若手研究（B）血管新生における新規因子Ninj1の機能解明　研究代表者　鹿原真樹
  3. 平成26-28年度　若手研究（B） 毛細血管幹細胞におけるApe1の役割解明―高性能化幹細胞調整法の開発にむけて、研究代表者　山内敦司

民間研究助成

  1. 平成23年度　秋山記念生命科学振興財団　研究助成　新生血管の成熟化制御機構の解明　川辺淳一（研究代表者）
  2. 平成22年度　先進医療研究振興財団　研究助成　Vasa vasorum血管新生における血管周囲末梢神経の役割　川辺淳一（研究代表者）
  3. 平成20年度　寿原記念財団　研究助成　内皮前駆細胞の機能制御に関する機序解明と、その臨床応用にむけての基礎研究　川辺淳一（研究代表者）
  4. 平成18年度　秋山記念生命科学財団　研究助成　プロスタノイドの血管病変形成における役割-骨髄細胞分化に及ぼす影響‐川辺淳一（研究代表者）